Tetrahydrocannabinolic acid is administered along with the phytocannabinoids in cannabis, especially cannabidiol and terpenes, the effect of cannabinoids can in certain circumstances be different alone. While researchers have identified more than 480 components in cannabis, including a number of compounds unique of the plant, scientists have not yet to determine how these chemical components work together to produce opposite reactions. The concept, "entourage effect," states that some cannabis compounds, which have no effect in isolation, affect the human body only when combined with any other components.


Cannabinoid science back in 1998 created a phrase called the 'Entourage effect' by Ben-Shabat and Raphael Mechoulam.

Raphael has carried out much research experimenting with cannabinoids, He was the first person to isolate the THC molecule, the compound within cannabis that gives the user the psychoactive effect that we call getting high! A TV reporter from the BBC was given THC on its own and made her feel sad and anxious but then when she was given CBD mixed with THC she became happier and more relaxed. That’s when DR Raphael Mechoulam realised that full plant extracts as opposed to isolated compounds played a much more beneficial effect within our bodies when taken as a whole plant extract he named this the ‘Entourage Effect’

Let me explain an example.. if you take a bite of an orange or an apple, your body releases enzymes that break down components of the orange and your body metabolizes it in a completely different way as if you were to take a vitamin C isolate similar to a vitamin C tablet. When sourcing a CBD oil product, be sure you purchase a full spectrum extract CBD oil.

Terpenes have recently come to light proving to play a beneficial vital roll in the 'Entourage Effect' as terpenes in the plant are inherent. These essential oils are not only beneficial to the entourage effect, they also give the plant a different variety of aromours.

Taking these essential oils alongside CBD oil creates the 'Entourage effect' We believe at MCU Botanicals the endocannabinoid system maintains health and homeostatus. All of our CBD product range contains whole-plant extracts and terpenoids that could really improve your life.


For people who have observed or experienced the entourage effect in cannabis, it may be difficult to understand why some people hesitate to recommend botanical cannabis use and prefer synthetics or isolates with only THC or CBD cannabinoids. Many people prefer to use a single compound because Western thought and philosophy endorses this isolated type of use. While this approach may unintentionally eliminate the entourage effect of cannabis, some people support this philosophy because it also serves to minimise any adverse side effects. However, to effectively use botanical cannabis, some researchers argue that people should reject the idea of creating a single potent supplement. Instead, these researchers believe that people should return to a philosophy of using a low dosage of a single, wide-range supplement. These scientists, including noted cannabis researcher Vincenzo Di Marzo, also believe that some people may suffer from an imbalance of some natural systems within the human body.


While the effect of CBD on THC is the most notable illustration of the entourage effect, research also indicates that cannabinoids and terpenes may also combine to achieve different results. In the whole-plant cannabis versus synthetic-cannabis debate, all researchers agree that the entourage effect is still not a concept that they fully understand. Further research into exactly how THC, CBD and other important cannabis compounds work will allow scientists to make better recommendations for how to use cannabis compounds in the near future. With nearly 500 different cannabis components to explore, the field of whole-plant and synthetic-cannabinoids is wide open for new and exciting developments.